1 Calne, D.B. and Mizuno, Y. (2004)
The neuromythology of Parkinson's Disease. Parkinsonism.
Relat. Disord. 10: 319-22. .
2 Newman, M.E. (2003) The structure
and function of complex networks. SIAM Review, 45(2):
167-256.
3 Barabasi, A.L. and Albert, R. (1999)
Emergence of scaling in random networks. Science,
286 (5439), 509-512.
4 Watts, D.J. and Strogatz, S.H.
(1998) Collective dynamics of 'small-world' networks.
Nature. 393(6684): 440-2.
5 Agnati, L.F. and Fuxe, K. (2000)
Volume transmission as a key feature of information
handling in the central nervous system possible new
interpretative value of the Turing's B-type machine.
Prog. Brain Res. 125: 3-19.
6 Agnati, L.F., Santarossa, L., Genedani,
S., Canela, E.I., Leo, G., Franco, R., Woods, A.,
Lluis, C., Ferrè, S. and Fuxe, K. (2004) On
the nested hierarchical organization of CNS: basic
characteristics of neuronal molecular networks. In:
Computational Neuroscience: cortical dynamycs, Lecture
Notes in Computer Sciences, Erdi P., Esposito A.,
Marinaro M., Scarpetta S., (Eds.), Springer, Berlin
Heidelberg New York , pp. 24-54.
7 Agnati, L.F., Tarakanov, A.O.,
Ferrè, S. and Fuxe, K. (2005) Receptor-receptor
interactions,receptor mosaics, and basic principles
of molecular network organization: possibile implications
for drug development. J. Mol. Neurosci. 26: 193-208.
8 Bucciantini, M., Giannoni, E.,
Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei,
N., Ramponi, G. et al. (2002) Inherent toxicity of
aggregates implies a common mechanism for protein
misfolding diseases. Nature 416: 507-11.
9 Stefani, M. and Dobson, C.M. (2003).
Protein aggregation and aggregate toxicity: new insights
into protein folding, misfolding diseases and biological
evolution. J. Mol. Med. 81:678-99.
10 Stefani, M. (2004) Protein misfolding
and aggregation: new examples in medicine and biology
of the dark side of the protein world. Biochim. Biophys.
Acta 1739:5-25.
11.Ross, C.A. and Poirier, M.A. (2005).
Opinion: What is the role of protein aggregation in
neurodegeneration? Nat. Rev. Mol. Cell. Biol. 6: 891-8.
12. Dobson, C.M. (2003) Protein folding
and misfolding. Nature 426: 884-90.
13. Prusiner, S.B., Scott, M., Foster,
D., Pan, K.M., Groth, D., Mirenda, C., Torchia, M.,
Yang, S.L., Serban, D., Carlson, G.A., et al. (1990)
Transgenetic studies implicate interactions between
homologous PrP isoforms in scrapie prion replication.
Cell. 63(4): 673-86.
14. Kellings, K., Meyer, N., Mirenda,
C., Prusiner, S.B. and Riesner, D. (1992) Further
analysis of nucleic acids in purified scrapie prion
preparations by improved return refocusing gel electrophoresis.
J. Gen. Virol. 73 ( Pt 4): 1025-9.
15 Chernoff, Y.O. (2004) Amyloidogenic
domains, prions and structural inheritance: rudiments
of early life or recent acquisition? Curr. Opin. Chem.
Biol. 8:665-71.
16 Baker, D. (2000) Surprising simplicity
to protein folding. Nature. 405(6782): 39-42.
17 Vendruscolo, M., Zurdo, J., MacPhee, C.E., and
Dobson, C.M. (2003) Protein folding and misfolding:
a paradigm of self-assembly and regulation in complex
biological systems.
Philos. Transact. A. Math. Phys. Eng. Sci. 361(1807):
1205-22.
18 Hartl, F.U. and Hayer-Hartl M.
(2002) Molecular chaperones in the cytosol: from nascent
chain to folded protein. Science 295:1852-8.
19 Muchowski, P.J. and Wacker, J.L.
(2005) Modulation of neurodegeneration by molecular
chaperones. Nat. Rev. Neurosci. 6:11-22.
20 Yerbury, J.J., Stewart, E.M.,
Wyatt, A.R. and Wilson, M.R. (2005) Quality control
of protein folding in extracellular space. EMBO, 6:
1131-6.
21 Lee, C. and Yu, M.H. (2005) Protein
folding and diseases. J. Biochem. Mol. Biol. 38: 275-80.
22 Agnati, L.F., Santarossa, L.,
Benfenati, F., Ferri, M., Morpurgo, A., Apolloni,
B. and Fuxe, K. (2002) Molecular basis of learning
and memory: modelling based on receptor mosaics. In
From Synapses to Rules, (eds B. Apolloni and F. Kurfes),
Kluwer Academic/Plenum Publishers, New York, pp. 165-96.
23 Agnati, L.F., Ferrè, S.,
Lluis, C., Franco, R. and Fuxe, K. (2003) Molecular
Mechanisms and therapeutical implications of intramembrane
receptor/receptor interactions among heptahelical
receptors with examples from the striatopallidal GABA
neurons. Pharmacol. Rev. 55: 509-50.
24 Agnati, L.F., Guidolin, D., Genedani,
S., Ferré, S., Bigiani, A., Woods, A.S. and
Fuxe, K. (2005) How proteins come together in the
plasma membrane and function in macromolecular assemblies:
focus on receptor mosaics. J. Mol. Neurosci. 26: 133-54.
25 Agnati, L.F., Leo, G., Zanardi,
A., Genedani, S., Rivera, A., Fuxe, K. and Guidolin,
D. (2006) Volume transmission and wiring transmission
from cellular to molecular networks: history and perspectives.
Acta Physiol. 187: 329-44.
26 Agnati L.F. (2006) Testo Atlante
di Fisiologia Umana: Apparato Renale. CEA, Milano.
27 Evanko, D.S., Zhang, Q., Zorec,
R. and Haydon, P.G. (2004) Defining pathways of loss
and secretion of chemical messengers from astrocytes.
Glia. 47: 233-40.
28 Monod, J., Changeux, J.P. and
Jacob, F. (1963) Allosteric proteins and cellular
control systems. J. Mol. Biol. 6:306-29.
29 Christopoulos, A. and Kenakin,
T. (2002) G protein-coupled receptor allosterism and
complexing. Pharmacol. Rev. 54: 323-74.
30 Koshland, D.E. Jr and Hamadani,
K. (2002) Proteomics and models for enzyme cooperativity.
J. Biol. Chem. 277:46841-4.
31 Agnati, L.F., Fuxe, K. and Ferrè
S. (2005) How receptor mosaics decode transmitter
signals. Possible relevance of cooperativity. Trends
Biochem. Sci. 30: 188-93.
32 Agnat,i L.F., Fuxe, K., Zoli,
M., Rondanini, C. and Ögren, S.O. (1982) New
vistas on synaptic plasticity: the receptor mosaic
hypothesis of the engram. Med. Biol. 60:183-190.
33 Agnati, L.F., Ferré, S.,
Leo, G., Lluis, C., Canela, E.I., Franco, R. and Fuxe
K. (2004) On the Molecular Basis of the Receptor Mosaic
Hypothesis of the Engram
J. Mol. Cell. Neurobiol., 24:501-516.
34 Agnati, L.F., Franzen, O., Ferré,
S., Leo, G., Franco, R. and Fuxe, K. (2003) Possibile
role of intramembrane receptor-receptor interactions
in memory and learning via formation of long-lived
heteromeric complexes: focus on motor learning in
the basal ganglia. J. Neural. Transm. 65:195-222.
35 Changeux, J.P., Devillers Thiery,
A. and Chemouilli, P. (1984) Acetylcholine receptor:
an allosteric protein. Science 225(4668): 1335-45.
36 Unger, J.W. (1998) Glial reaction
in aging and Alzheimer's Disease. Microsc. Res. Tech.
43:24-8.
37 Roher, A.E., Baudry, J., Chaney,
M.O., Kuo, Y.M., Stine, W. B. and Emmerling, M.R.
(2000) Oligomerization and fibril assembly of the
amyloid-beta protein. Biochim. Biophys. Acta 1502:
31-43.
38 Selkoe, D.J. (2003) Aging, amyloid
and Alzheimer's disease: A perspective in honor of
Carl Cotman. Neurochem. Res. 28:1705-13.
39 Lee, H.G., Castellani, R.J., Zhu,
X., Perry, G. and Smith, M.A. (2005) Amyloid-? in
Alzheimer's disease: the horse or the cart? Pathogenetic
or protective? Int. J. Exp. Path. 86:133-8.
40 Gong, Y., Chang, L., Viola, K.L.,
Lacor, P.N., Lambert, M.P., Finch, C.E., Krafft, G.A.
and Klein, W.L. (2003) Alzheimer's disease-affected
brain: Presence of oligomeric A_ ligands (ADDLs) suggests
a molecular basis for reversible memory loss. Proc.
Natl. Acad. Sci. USA 100:10417-22.
41 Lacor, P.N., Buniel, M.C., Chang,
L., Fernandez, S.J., Gong, Y., Viola, K.L., Lambert,
M.P., Velasco, P.T. et al. (2004) Synaptic Targeting
by Alzheimer's-Related Amyloid Oligomers. J. Neurosci.
24: 10191-200.
42 Lambert, M.P., Barlow, A.K., Chromy,
B.A., Edwards, C., Freed, R. Liosatos, M. Morgan,
T.E., Rozovsky I. et al. (1998) Diffusible, nonfibrillar
ligands derived from Ab1-42 are potent central nervous
system neurotoxins. Proc. Natl. Acad. Sci. USA 95:6448-53.
43 Stephan, A., Laroche, S. and Davis,
S. (2001) Generation of aggregated -amyloid in the
rat hippocampus impairs synaptic transmission and
plasticity and causes memory deficits. J. Neurosci.
21: 5703-14.
44 Foguel, D. and Silva, J.L. (2004)
New insights into the mechanisms of protein misfolding
and aggregation in amyloidogenic diseases derived
from pressure studies. Biochemistry 43(36): 11361-11370.
45 Seshadri, S., Beiser, A., Selhub,
J., Jacques, P.F., Rosenberg, I.H., D'Agostino, R.B.,
Wilson, P.W. and Wolf, P.A. (2002) Plasma homocysteine
as a risk factor for dementia and Alzheimer's disease.
N. Engl. J. Med. 346(7): 476-83.
46 Ho, P.I., Collins, S.C., Dhitavat,
S., Ortiz, D., Ashline, D., Rogers, E. and Shea, T.B.
(2001) Homocysteine potentiates beta-amyloid neurotoxicity:
role of oxidative stress. J. Neurochem. 78(2): 249-53.
47 Prusiner, S.B. (1997) Prion Diseases
and the BSE Crisis. Science 278: 245-51.
48 Prusiner, S.B. (1998) Prions.
Proc. Natl. Acad. Sci. U. S. A. 95(23),13363-13383
49 Campana, V., Sarnataro, D. and
Zurzolo, C. (2005) The highways and byways of prion
protein trafficking. Trends Cell Biol. 15(2):102-111.
50 Stahl, N., Baldwin, M.A., Teplow,
D.B., Hood, L., Gibson, B.W., Burlingame, A.L. and
Prusiner, S.B. (1993) Structural studies of the scrapie
prion protein using mass spectrometry and amino acid
sequencing. Biochemistry 32: 1991-2002.
51 James, T.L. Liu, H., Ulyanov,
N.B., Farr-Jones, S., Zhang, H., Donne, D.G., Kaneko,
K., Groth, D. et al. (1997) Solution structure of
a 142-residue recombinant prion protein corresponding
to the infectious fragment of the scrapie isoform.
Proc. Natl. Acad. Sci. USA 94:10086-91.
52 DeMarco, M.L. and Daggett, V.
(2005) Local environmental effects on the structure
of the prion protein. C R Biologies 328:847-62.
53 Aguzzi, A. and Weissmann, C. (1997)
Prion research: the next frontiers. Nature 389: 795-8.
54 Cortelli, P., Gambetti, P., Montagna,
P. and Lugaresi, E. (1999) Fatal familial insomnia:
clinical features and molecular genetics. J. Sleep
Res. Suppl 1:23-9.
55 Carulla, N., Caddy, G.L., Hall,
D.R., Zurdo, J., Gairi, M., Feliz, M., Giralt, E.,
Robinson, C.V. and Dobson, C.M. (2005) Molecular recycling
within amyloid fibrils. Nature 436(7050): 554-8.
56 Kelly, J.V. and Balch, W.E. (2003)
Amyloid as a natural product. J. Cell. Biol. 161(3),
461-2.
57 Si, K., Lindquist, S. and Kandel,
E.R (2003) A neuronal isoform of the aplysia CPEB
has prion-like properties. Cell 115(7), 879-91.
58 Luhrs, T., Ritter, C., Adrian,
M., Riek-Loher, D., Bohrmann, B., Dobeli, H., Schubert,
D. and Riek, R. (2005) 3D structure of Alzheimer's
amyloid-beta(1-42) fibrils. Proc. Natl. Acad. Sci.
U. S. A., 102(48), 17342-7.
59 Agnati, L.F., Zunarelli, E., Genedani,
S. and Fuxe, K. (2006) On the existence of a global
molecular network enmeshing the whole central nervous
system: physiological and pathological implications.
Curr. Protein. Pept. Sci. 7(1): 3-15.
60 Van Horssen, J., Wesseling, P.,
van den Heuvel, L.P., de Waal, R.M. and Verbeek, M.M.
(2003) Heparan sulphate proteoglycans in Alzheimer's
Disease and amyloid-related disorders. Lancet Neurol.
2:482-92.
61 Paratcha, G. and Ibanez, C.F.
(2002) Lipid rafts and the control of neurotrophic
factor signaling in the nervous system: variations
on a theme. Curr. Opin. Neurobiol. 12, 542-9.
62 Eyal, A., Szargel, R., Avraham,
E., Liani, E., Haskin, J., Rott, R. and Engelender,
S. (2006) Synphilin-1A: An aggregation-prone isoform
of synphilin-1 that causes neuronal death and is present
in aggregates from -synucleinopathy patients. Proc.
Natl. Acad. Sci. USA 103:5917-22.
63 Agnati, L.F., Genedani, S., Leo,
G., Forni, A., Woods, A.S., Filaferro, M. and Fuxe,
K. (2006) Ab peptides as one of the crucial Volume
Transmission signals in the trophic units and their
interactions with homocysteine. Physiological implications
and relevance for Alzheimer's disease. J. Neural.
Transm. In press.